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| The correlation relationship between the serum alpha-fetoprotein, human chorionic gonadotropin, and angiogenin levels of pregnant women with recurrent spontaneous abortion and their early abortion |
| Guang'an People's Hospital, Guang'an, Sichuan Province, 638000 |
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Abstract To explore the relationship between the serum alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and angiopoietin levels of pregnant women with recurrent spontaneous abortion and their early abortion. Methods: A total of 112 pregnant women who had accepted curettage because of abortion were enrolled as the research objects from May 2019 to May 2020, which included 60 pregnant women with once abortion in control group and 52 cases with over once abortion in study group. The levels of serum AFP and HCG of the women in the two groups were detected by full-automatic electrochemical luminescence analyzer. The expression levels of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in chorion and decidua tissues of the women in the two groups were detected by immunohistochemical SP method. Results: The levels of serum AFP (3.15±0.24 ng/ml) and HCG (78.16±3.67 IU/L) of the women in the study group were significantly lower than those (8.35±1.62 ng/ml and 89.74±4.58 IU/L) of the women in the control group. Pearson correlation analysis showed that the serum AFP level of the women in the two groups was positively correlated with their HCG level (P＜0.05). Pathological section analysis showed that the levels of intracytoplasm Ang-1 and Ang-2 were expressed in trophoblast cells, cytoplasm of mesenchymal cells of villus tissue, and in glandular epithelial cells and stroma cells of decidua tissue of the women in both groups, but the expressions of Ang-1 and Ang-2 in villus tissue of the women in the study group were significantly higher than those of the women in the control group, but which in the decidua tissue of the women in the study group were significantly lower (all P＜0.05). Conclusion: The levels of serum AFP and HCG of the pregnant women with recurrent spontaneous abortion during the first trimester of pregnancy are abnormal decreasing, and the AFP level is positive correlation with the HCG level. The Ang-1 and Ang-2 in chorion and decidua tissues are overexpression, which indicate that the detections of serum AFP and HCG of the pregnant women with recurrent spontaneous abortion during the first trimester of pregnancy is benefit to the prognosis of these women. The normal expression of angiopoietin in chorion tissues of the pregnant women is of important roles in maintaining normal pregnancy.
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