To analyze the effect of 0.1% ropivacaine combined with nalbuphine for epidural labor analgesia.Methods: 300 singleton primiparas with full-term were selected and were divided two groups according the serial number of the primiparas and alternating manner from December 2018 to May 2020f.The women in the control group were given 0.1% ropivacaine combined with 0.5μg/mL sufentanil for epidural labor analgesia, and the women in the observation group were given 0.1% ropivacaine combined with 0.2 mg/mL nalbuphine for epidural labor analgesia.The score of visual analogue scale (VAS) before analgesia(T0), at 15 minutes after analgesia (T1), at 30 minutes after analgesia(T2), and at cervix uteri full opening (T3), and 1min Apgar score of newborns, 24h newborn neurobehavioral score (NABA), PH value and lactic acid level of umbilical artery blood immediately after delivery, and the adverse reactions rate were compared between two group.Results: VAS score of the women in both groups at T0 had increased significantly, but which had decreased significantly after treatment (P＜0.05).There was no significant difference in VAS score of the women at T0-T3 between the two groups (P＞0.05).There were no significant differences in Apgar score at 1 min, the NABA score at 24 h, the value of umbilical blood PH, and the lactic acid level of the women immediately after delivery between the two groups (P＞0.05).There was no significant difference in the incidence of nausea and vomiting of the women between the two groups.The rates of urinary retention (16.5%) and pruritus (1.6%), and the total incidence of adverse reactions (21.3%) of the women in the observation group were significantly lower than those (6.9%, 9.9%, and 45.8%) of the women in the control group (P＜0.05).Conclusion: 0.1% ropivacaine combined with nalbuphine for epidural labor analgesia has good analgesic effect with better safety, which is an effective scheme for epidural labor analgesia.