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| Influence of pre-pregnancy body mass index and gestational weight gain of pregnant women on their gestational diabetes mellitus and their interaction |
| 1.School of Public Health, Capital Medical University, Beijing Key Laboratory of Clinical Epidemiology, Beijing, 100069; 2. Xuanwu Hospital, Capital Medical University |
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Abstract To investigate the influence of body mass index (BMI) before pregnancy and gestational weight gain (GWG) of pregnant women on their gestational diabetes mellitus (GDM). Methods: Retrospective cohort study method was used to collect the data of 4524 delivered women in Xuanwu Hospital from 2017 to 2021. The incidence of GDM of the women with different pre-pregnancy BMI and GWG (in different groups) was compared. Logistic regression was used to compare the occurrence and the influencing factors of GDM of the women in different groups. Multiplication and additive models were used to analyze the interaction between prepregnancy BMI and GWG influenced on GDM. Results: Overweight, obesity before pregnancy, and the insufficient GWG were the risk factors of GDM (OR=1.46, 95%CI: 1.22-1.75; OR=2.17, 95% CI: 1.68-2.80; and OR=1.74, 95%CI: 1.45-2.09), and the low body weight before pregnancy and the excessive GWG were the protective factors of GDM (OR=0.67, 95%CI: 0.51-0.89; OR=0.83, 95% CI: 0.71-0.98). Weight standard before pregnancy insufficient GWG was the risk factor of GDM (OR=1.95, 95%CI: 1.55-2.45)，and overweight before pregnancy-excess GWG was the protective factor of GDM (OR=0.54, 95%CI: 0.38-0.77). Multiplication model and additive model showed there was no interaction between prepregnancy BMI and GWG influenced on GDM. Conclusion: Both prepregnancy BMI and GWG can affect GDM occurrence, but there was no statistical interaction between prepregnancy BMI and GWG influenced on GDM.
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