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| Comparison of the effect of uterine artery embolization by different diameter gelatin sponges combined with methotrexate for treating women with uterine scar pregnancy and their influence on their ovarian function |
| Xuzhou Central Hospital, Jiangsu Province, 221009 |
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Abstract To investigate the effect of uterine artery embolization by different diameter gelatin sponges combined with methotrexate for treating women with uterine scar pregnancy (CSP), and to study its influence on the ovarian function of these women.Methods: 100 women with CSP were selected and were treated by uterine artery embolization of gelatin sponges combined with methotrexate from February 2018 to May 2020.These women were divided into group A (35 women given uterine artery embolization with 1mm diameter of gelatin sponge), group B (32 women given uterine artery embolization with 500um-700um diameter of gelatin sponge), and group C (33 women given uterine artery embolization with gelatin sponge with 1000um-1400um diameter of gelatin sponge) according to the different diameters of the gelatin sponge.The total blood loss, the cost of interventional surgery, and the time of β-HCC returned to normal of the women were compared among the three groups.The levels of serum β-human chorionic vinegar gonadotropin (β-HCG), estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) of the women before and after treatment were observed.The adverse reactions situation of the women was analyzed.Results: There were no significant differences in total blood loss and the time of β-HCC returned to normal of the women among the three groups (P＞0.05).The cost of surgery of the women in group A was significantly lower than that of the women in group B or group C (P＜0.05).There were significant differences in the levels of βHCG and LH of the women in the three groups among different time (P＞0.05), but which of the women had no significant different among the three groups (P＜0.05).The β-HCG level of the women in the three groups in 2d, 7d, and 21d after treatment were significantly lower than those before treatment (P＜0.05).There were no significant differences in the levels of E2, LH, and FSH, and the incidence of total adverse reactions of the women among the three groups (all P＞0.05).There was no any woman with stomachache in group A.Conclusion: 1mm diameter of gelatin sponge strip combined with methotrexate for treating women with uterine scar pregnancy can achieve the same effect as other diameter of gelatin sponges with lower cost and higher safety.
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