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| Correlation between the serum miR-3607-3p level of patients with cervical cancer and their human papillomavirus infection |
| Nanyang Central Hospital, Nanyang, Henan Province 473000 |
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Abstract To study the correlation between the serum miR-3607-3p expressionlevel of patients with cervical cancer and their human papillomavirus (HPV) infection. Methods: The clinical data of 74 patients who underwent cervical biopsy from August 2018 to February 2020 were selected in the research objects. According to the results of pathological examination, these patients were divided into 18 patients with cervicitis in group A, 31 patients with squamous intraepithelial lesion (SIL) in group B, and 25 patients with cervical cancer in group C. The levels of serum miR-3607-3p and the expressions of HPV-DNA and HPV E6/E7 mRNA in cervical exfoliated cells of the patients in the three groups were detected. Spearman analysis was used to analyze the correlation between the miR-3607-3p level of the patients and their HPV infection. Multivariate Logistic regression was used to analyze the risk factors affecting the occurrence of cervical cancer. Results: The serum Mir-3607-3p level of the patients in group A, in group B, and in group C were 0.98±0.16, 0.64±0.15, and 0.34±0.13, respectively, which had decreased gradually, but the HPV positive expression rate and HPV E6/E7 mRNA high load rate of the patients in group A, in group B, and in group C had increased gradually (all P＜0.05). The serum Mir-3607-3p level of the patients in group C was negatively correlated with their HPV positive expression and HPV E6/E7 mRNA expression (r=-0.541,-0.492, P=0.000), and the Mir-3607-3p level was a protective factor of the occurrence of cervical cancer. HPV positive expression and high load of HPV E6/E7 mRNA were the risk factors of the occurrence of cervical cancer (P＜0.05). Conclusion: The expression level of serum miR-3607-3p of the patients with cervical cancer is low, which is negatively correlated with their HPV infection. The level of serum miR-3607-3p can be used as a potential biological index for screening cervical cancer.
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