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| Influence of preoperative administration of naborphine on the pain degree and the inflammatory factor expression level of the patients after laparoscopic hysterectomy |
| The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052 |
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Abstract To investigate the influence of preoperative administration of naborphine on the pain degree and the high mobility group protein B1 (HMGB1) expression level of the patients after laparoscopic hysterectomy. Methods: From January 2019 to January 2020, 80 patients who underwent laparoscopic hysterectomy were selected as the study objects, and were randomly divided into study group and control group (40 cases in each group) according to the digital table method. The patients in the study group were injected 0.2 mg/kg of nabufine hydrochloride intravenously at 10 minutes before anesthesia induction, and the patients in the control group were given the same amount of normal saline intravenously at 10 minutes before anesthesia induction. The changes of the vital signs indexes values, the levels of serum HMGB1, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and the pain degree of the patients in the two groups at different time of anesthesia were observed. The adverse reactions of the patients in the two groups were evaluated. Results: There were no significant differences in the values of mean arterial pressure (MAP) and heart rate (HR), and the levels of serum HMGB1 expression, IL-6, and TNF-α of the patients at 30 min before anesthesia induction (T1) between the two groups (P>0.05). The values of MAP and HR, and the levels of serum HMGB1 expression, IL-6, and TNF-α of the patients in the two groups at 2 h after operation (T2), 6 h after operation (T3), and 12 h after operation (T4) were significantly higher than those at T1, and which of the patients in the study group were significantly lower than those of the patients in the control group (P<0.05). The visual analogue scale (VAS) scores of the patients at T2 (4.00±0.78 points), T3 (3.27±0.52 points), and T4 (2.11±0.43 points) in the study group were significantly lower than those (4.57±0.85 points, 3.75±0.64 points, and 2.11±0.43 points) of the patients in the control group. The incidence of total postoperative adverse reactions (7.5 %) of the patients in the study group was significantly lower than that (35%) in the control group (all P<0.05). Conclusion: The preoperative administration of naborphine of the patients with laparoscopic hysterectomy can effectively improve their postoperative pain degree, can reduce their body inflammatory response and postoperative adverse reactions.
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