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| Risk assessment of high-grade cervical lesions of patients with high-risk human papillomavirus complicated with sexually transmitted pathogens infection |
| Haishu District Hospital of Traditional Chinese Medicine, Ningbo, Zhejiang Province, 315100 |
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Abstract To analyze the correlation between the sexually transmitted pathogen infection of patients with high-risk human papillomavirus (HR-HPV) infection and their high-grade cervical lesions. Methods: 370 patients with positive HR-HPV who underwent cervical thin-layer liquid based cytology test (TCT) and colposcopic cervical biopsy from January 2015 to July 2020 were selected as study subjects. According to the TCT results, these patients were divided into group A1 (177 cases with normal cervical cytology), group A2 (104 cases with cervical cytology≤LSIL), and group A3 (89 cases with cervical cytology≥HSIL). According to the cervical histopathological results, these patients were also divided into group B1 (189 cases with normal cervical cytology or cervical inflammation), group B2 (99 cases with cervical intraepithelial neoplasias (CIN) I–II), and group B3 (86 cases with CIN Ⅲ or cervical cancer). PCR and diversion hybridization were used to detect the sexually transmitted pathogens in cervical exfoliated cells of these patients. Results: The infection rates of CT, UP, and UU of the patients in group A1, group A2, and group A3 had increased gradually (P<0.05), the infection rates of NG and HSV-2 of the patients in group A3 were significantly higher than those of the patients in group A1 (P<0.05), and there was no significant differences in the infection rates of NG and HSV-2 of the patients between group A1 and group A2 (P>0.05). The single infection rate of sexually transmitted pathogens of the patients in group A3 was significantly higher than that of the patients in group A1 or group A2 (P<0.05), and which of the patients had no significant different between group A1 and group A2 (P>0.05). The rate of multiple infection of the patients in group A1, group A2, and group A3 had increased gradually (P<0.05). The infection rates of UP and UU of the patients in group B1, group B2, and group B3 had increased gradually (P<0.05), the infection rates of NG and HSV-2 of the patients in group B3 were significantly higher than those of the patients in group B1 (P<0.05), there was no significant differences in the infection rates of NG and HSV-2 of the patients between group B1 and group B2 (P>0.05), and the CT infection rates of the patients in group B2 and group B3 were significantly higher than those of the patients in group B1 (P<0.05). There was no significant difference in CT infection rate of the patients between group B2 and group B3 (P>0.05), but the single infection rate and multiple infection rate of the patients in group B1, group B2, and group B3 had increased gradually (P<0.05). The UP infection and the multiple infection of the patients were the independent influencing factors of their cervical cytology ≥HSIL (P<0.05), the CT and UU infections of the patients had no correlation with their cervical cytology ≥HSIL (P>0.05), the UP infection and multiple infection of the patients were the independent influencing factors of their cervical histopathological results (P<0.05). The CT and UU infections of the patients had no correlation with their cervical histopathological results (P>0.05). Conclusion: UP infection and multiple sexually transmitted pathogen infection of the patients with positive HR-HPV may increase the risk of their high-grade cervical lesions, which is worthy of clinical attention.
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