|
|
|
| The influence of group B streptococcus infection of pregnant women during the third trimester of pregnancy on their blood coagulation function, vaginal cleanliness, and maternal and infant outcomes |
| Hubei Provincial Hospital of Integrated Chinese and Western Medicine，Wuhan, Hubei Province, 430015 |
|
|
|
|
Abstract To explore the influence of group B streptococcus (GBS) infection of pregnant women during the third trimester of pregnancy on their blood coagulation function, vaginal cleanliness, and maternal and infant outcomes. Methods: The clinical data of 986 pregnant women during 35-42 gestational weeks from January 2019 to October 2019 were collected retrospectively. All the pregnant women were tested for vaginal cleanliness and were cultured GBS in vaginal secretion. According to the culture results of GBS, these women were divided into group A (women with GBS-positive) and group B (women with GBS-negative). The coagulation function and vaginal cleanliness of the women were compared between the two groups. And according the treatment, the women in group A were also divided into group A1 (women with normal treatment) and group A2 (women without normal treatment). The maternal and infant outcomes in group A1 and group A2 were statistics analyzed. Results: There were 92 (9.3%) women with GBS-positive in group A. The values of plasma prothrombin time (PT), activated partial thrombin time (APTT), international standardized ratio (INR), and the levels of D-dimer (D-D) and fibrinogen degradation product (FDP) of the women in group A were significant lower than those of the women in group B, while the levels of fibrinogen (Fbg) and antithrombin -3 (AT-3) of the women in group A were significant higher than those of the women in group B (P<0.05). The proportion of abnormal vaginal cleanliness (62.0%) of the women in group A was significant higher than that (34.8%) of the women in group B (P<0.05). The proportions of adverse maternal and infant outcomes, such as premature rupture of membranes, premature delivery, neonatal infection, and neonatal pathological jaundice of the women in group A1 were significant lower than those of the women in group A2. Conclusion: GBS infection of pregnant women during the third trimester of pregnancy will not only cause coagulation dysfunction, decrease vaginal cleanliness, but also induce adverse maternal and infant outcomes. Therefore, it is necessary to carry out GBS examination of the pregnant women during the third trimester of pregnancy in time.
|
|
|
|
|
|
|
|
|
