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| Effect of combined spinal-epidural anesthesia and epidural anesthesia during cesarean section of elderly pregnant women and their influence on the maternal immunologic function |
| The Third People's Hospital of Bengbu, Bengbu, Anhui Province, 233000 |
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Abstract To analyze the anesthesia effect of combined spinal-epidural anesthesia and epidural anesthesia during cesarean section of elderly pregnant women, and to study their influence on the maternal immunologic function. Methods: A total of 100 elderly pregnant women who wanted cesarean section were selected as the research subjects, and were randomly divided into observation group and control group (50 cases in each group) from Septenber 2017 to Septenber 2020. The women in the observation group were given combined spinal-epidural anesthesia, while the women in the control group were given epidural anesthesia. The anesthesia effect, the values of hemodynamic indexes and immune function indexes, and the rate of adverse reactions of the women in the two groups were analyzed. Results: There were 20(40.0%) cases with grade Ⅲ of anesthetic effect, 23(46.0%) cases with grade II of anesthetic effect, and 7(14.0%) cases with grade I of anesthetic effect in the observation group. There were 10(20.0%) cases with grade Ⅲ of anesthetic effect, 21(42.0%) cases with grade II of anesthetic effect, and 19(38.0%) cases with grade I of anesthetic effect in the control group. The anesthesia effect of the women in the observation group was significantly better than that of the women in the control group (P<0.05). The values of heart rate, systolic blood pressure, and mean arterial pressure of the women in both groups had increased significantly after anesthesia, but the change ranges of which of the women in observation group were significantly lower than those of the women in control group (all P<0.05). The levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG, and IGM of the women in both groups were significantly lower than those before anesthesia, while CD8+ level of the women in both groups at 12h after operation was significantly higher than that before anesthesia, and change ranges of which of the women in observation group were significantly lower than those of the women in control group (all P<0.05). The incidence of adverse reactions during anesthesia and after operation (10.0% and 14.0%) of the women in the observation group were significantly lower than those (28.0% and 32.0%) of the women in the control group (P<0.05). Conclusion: Compared with that of epidural anesthesia, combined spinal-epidural anesthesia has better anesthesia effect during cesarean section of elderly pregnant women, and which can effectively alleviate their immune function inhibition, and help to improve their postoperative recovery.
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