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Abstract To explore the effects of ultrasound-guided posterior quadratus lumborum block (QLB) during laparoscopic hysterectomy of patients on their stress level and microcirculation. Methods: 86 patients who wanted to laparoscopic hysterectomy were selected and were divided into control group and observation group (43 cases in each group) according to the random number table method from April 2019 to September 2019. The patients in the control group were given patientcontrolled intravenous analgesia (PCIA), while the patients in the observation group were given PCIA combined with ultrasound-guided posterior QLB analgesia. The differences of pain degree ［visual analogue scale (VAS)］, the levels of stress indexes ［angiotensin II (Ang-II), cortisol (Cor)］, and microcirculation parameters (loop morphology integral and blood flow integral in nail fold microcirculation) of the patients at 2h (T1), 4h (T2), 12h (T3) and 24h (T4) after surgery were compared between the two groups. The incidences of analgesic remediation, analgesia satisfaction, and adverse reactions of the patients in the two groups at 24h after surgery were recorded. Results: The VAS score, the levels of serum stress indexes, such as Ang-II and Cor, and the scores of microcirculation parameters, such as loop morphology integral and blood flow integral in nail fold microcirculation, of the patients in the two groups at T1, T2, T3, and T4 had decreased gradually, and which of the patients in the observation group at T2, T3, and T4 were significantly lower than those of the patients in the control group (all P<0.05). The incidence of analgesic remediation (9.3%) of the patients in the observation group at 24h after surgery was significantly lower than that (25.6%) of the patients in the control group (P<0.05), and the analgesia satisfaction (69.8%) of the patients in the observation group at 24h after surgery was significantly better than that (34.9%) of the patients in the control group (P<0.05). There was no significant difference in the rate of adverse reactions (9.3% vs.14.0%) of the patients between the two groups (P>0.05). Conclusion: Ultrasound-guided posterior QLB during laparoscopic hysterectomy has good analgesic effect, and can reduce postoperative stress response and improve microcirculation of the patients with good safety.
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