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| Influence of hypothyroidism of the women during the third trimester of pregnancy on their glucose and lipid metabolism, heart function, and pregnancy outcomes |
| 1.Taizhou Women and Children's Hospital Affiliated to Wenzhou Medical University, Taizhou, Zhejiang Province, 318000; 2. Taizhou Central Hospital |
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Abstract To explore the effects of hypothyroidism of the women during the third trimester of pregnancy on their glucose and lipid metabolism, heart function, and pregnancy outcomes. Methods: 70 pregnant women with hypothyroidism during the third trimester of pregnancy were selected in observation group from January 2019 to January 2020, and 70 healthy pregnant women during the third trimester of pregnancy were selected in control group during the same period. The indicators of thyroid hormone biochemical, blood glucose and blood lipid metabolism, and echocardiogram of the women were compared between the two groups, and the pregnancy outcomes of the women in the two groups were analyzed. Results: The levels of serum thyroid hormone and the serum FT3 and FT4 levels of the women in the observation group had significant different from those of the women in the control group. The levels of glucose and lipid metabolism indexes of the women in the observation group were significantly higher than those of the women in the control group (P＜0.05). The values of echocardiography index of the women in the observation group had significant different from those of the women in the control group (P＜0.05). The incidences of placental abnormality (11.4%), fetal growth restriction (12.9%), preterm birth (21.4%), and neonatal asphyxia (15.7%) in the observation group were significantly higher than those (1.4%, 1.4%, 8.6%, and 4.3%) in the control group (P＜0.05), but there were no significant differences in the incidences of adverse pregnancy, such as polyhydramnios, premature rupture of membranes, fetal distress, low birth weight, and macrosomia between the two groups (P＞0.05). Conclusion: Hypothyroidism of the women during the third trimester of pregnancy can cause their glucose and lipid metabolism dysfunction and affect their heart function, which can increase the incidence of adverse pregnancy outcomes. Clinically, timely intervention measures should be taken for the pregnant women with hypothyroidism to reduce the adverse effects of the disease on pregnant women and their fetuses.
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