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| Indexes of oxidative stress and insulin resistance of pregnant women with gestational diabetes mellitus and hypertensive disorders of pregnancy |
| Putuo District People's Hospital of Zhoushan, Zhejiang Province, 316100 |
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Abstract To analyze the changes of oxidative stress indexes of pregnant women with gestational diabetes mellitus (GDM) combined with hypertensive disorders of pregnancy (HDP), and to study their relationship with the insulin resistance of the women. Methods: From January 2016 to September 2019, 53 pregnant women with GDM and HDP were selected in group A, 106 pregnant women with GDM alone were selected in group B, and 106 pregnant women with normal blood pressure value and blood glucose level were selected in group C. The differences of oxidative stress indexes, such as MDA, AOPPs, LHP, T AOC of the women were compared among the three groups, and which’s correlation with the insulin resistance of the women was analyzed. Results: The levels of serum MDA, AOPPs, and LHP of the women in group C were the lowest, then followed by those of the women in group B, and which of the women in group A were the highest. The T AOC level of the women in group C were the highest, then followed by those of the women in group B, and which of the women in group A were the lowest (P＜0.05). The levels of serum MDA, AOPPs, and T AOC had predictive effects for GDM and HDP occurrences of the women (P＜0.05). The OGTT time, the area under of the blood glucose curve, the serum FPG and FINS levels, the HOMA-IR value of the women in group A and group B were significantly higher than those of the women in group C, but the HOMA-β value of the women in group A and group B was significantly lower. The OGTT time, the area under of the blood glucose curve, the serum FINS level, and the HOMA-IR value of the women in group A were significantly higher than those of the women in group B, and the HOMA-β value of the women in group A was significantly lower (all P＜0.05), but there was no significant difference in the FPG level of the women between group A and group B (P＞0.05). In group B, the serum MDA and AOPPs levels of the women were positively correlated with their HOMA-IR value (P＜0.05), the T-AOC level of the women was negatively correlated with their HOMA-IR value (P＜0.05), but the serum LHP level of the women was no correlated with their HOMA-IR value (P＞0.05). In group A, the serum MDA, AOPPs, and LHP levels of the women were positively correlated with their HOMA-IR value (P＜0.05), while the T AOC level of the women was negatively correlated with their HOMA-IR value (P＜0.05). Conclusion: The oxidative stress injury of the pregnant women with GDM and HDP is more serious, the pathophysiological states of GDM and HDP of the women are promoting each other.
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