To explore the expression of Mir-150 and Mir-155 in the villi tissue of women with recurrent spontaneous abortion(RSA), and to study the expression of Mir-150 and Mir-155 relevant to the angiogenesis factor of the women. Methods: 60 women with RSA from March 2019 to June 2020 were selected in study group, and 60 women with early abortion were selected in control group during the same period. The expressions of Mir-150, Mir-155, apoptosis-promoting molecules, anti-apoptotic molecules, and angiogenic molecules in the villi tissue of the women in the two groups were detected. And the levels of Mir-150, Mir-155, and angiogenic molecules in the villi of the women were compared between the two groups. Results: The expression of mir-150 of the women in the study group was significantly higher than that of the women in the control group, but the mir-155 expression of the women in the study group was significantly lower. In the study group, the expression of Mir-150 of the women with ≥4 times of miscarriages was significantly higher than that of the women with <3 miscarriages, but the expression of mir-155 of the women with ≥4 times of miscarriages was significantly lower than that of the women with < 3 times of miscarriages(all P<0.05). The levels of mRNA and protein of Bax, Bad, Fas, Fasl, and the soluble vascular endothelial growth factor receptor(SFLT-1) of the women in the study group were significantly higher than those of the women in the control group, but the levels of mRNA and protein of Bcl-2, Bcl-XL, and the vascular endothelial growth factor(VEGF) and hypoxia-inducible factor-1(HIF-1α) of the women in the study group were significantly lower than those of the women in the control group(all P<0.05). Spearman correlation analysis showed that the levels of mRNA and protein of Bax, Bad, Fas, Fasl, and SFLT-1 of the women were positively correlated with their miR-150 level, but were negatively correlated with their miR-155 level(P<0.05), and the levels of mRNA and protein of Bcl-2, Bcl-XL, VEGF, and HIF-1α of the women were positively correlated with their miR-150 level, but were negatively correlated with their miR-155 level(P<0.05). Conclusion: The expression of miR150 in villi of the women with RSA is high, but the expression of miR155 in villi is low. The miR150 level is negatively correlated with angiogenesis, while miR155 level is positively correlated with angiogenesis.