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| Association study between paternal smoking and spontaneous abortion of women with reproductive age in rural Yunnan |
| Yunnan Population and Family Planning Research Institute, National Health Commission Key Laboratory of Periconception Health Birth In Western China, Key Laboratory of Fertility Regulation and Minority Birth Health Research of Yunnan Province, Kunming, Yunnan Province, 650021 |
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Abstract To explore the relationship between paternal smoking and spontaneous abortion of women with reproductive age in rural Yunnan. Method：195635 rural couples who had participated in the National Free Pre-pregnancy Checkups Project from 2015 to 2019 in Yunnan province were selected as study objects and were followed up till to their pregnancy outcomes. The relationship between paternal smoking and the spontaneous abortion of the women with reproductive age was analyzed. Result: Logistic regression analysis showed that paternal smoking increased the risk of spontaneous abortion of the women with reproductive age in rural Yunnan(OR=1.059, 95% CI: 1.011-1.108). The risk of spontaneous abortion of the women was consistent with the increasing trend of their husband's daily smoking(Z=435.408, P<0.001). The risk of spontaneous abortion of the women with their husband's daily smoking more than 20 cigarettes had increased significantly(OR=1.098, 95% CI: 1.025-1.176). Paternal quitting smoking during periceonceptional period was a protective factor of the spontaneous abortion(OR=0.862, 95% CI：0.801-0.928). Conclusion: Paternal smoking of the women increases their risk of spontaneous abortion in rural areas of Yunnan province, and the risk of spontaneous abortion increases with the increasing of paternal daily cigarette number. The risk of the spontaneous abortion significantly increases when the amount of smoking reached 20 cigarettes per day or more. Paternal quitting smoking during periceonceptional period is a protective factor of the spontaneous abortion of the women.
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