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| The levels of serum CA199 and HE4 expressions of the women after laparoscopic ovarian cyst resection and its association with the change of sex hormone |
| Taihe County People's Hospital, Fuyang, Anhui Province, 236600 |
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Abstract To detect the expression levels of serum carbohydrate antigen 199 (CA199) and human epididymal protein 4 (HE4) of the women with ovarian cyst, and to analyze the influence of CA199 and HE4 levels on the ovarian function after laparoscopic ovarian cyst resection. Methods: 106 women with ovarian cysts who wanted laparoscopic ovarian cyst resection were selected in group A, and 102 women who wanted conventional open ovarian cysts were selected in group B from January 2016 to January 2019. The serum CA199 and HE4 levels of the women in the two groups were detected before and 24 h after surgery. Pearson method was used to analyze the relationship between the CA199 and HE4 levels of the women and their levels of postoperative serum estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH), and their efficacy. Results: The postoperative blood loss (38.5±12.2ml), the first exhaust time (17.3±5.0h), and the time of hospital stay (6.4±1.3d) of the women in group A were significant lower than those of the women in group B, but the total effective rate (95.3%) of the women in group A was significant higher than that (84.3%) of the women in group B (P＜0.05).The levels of serum CA199, HE4, and E2, and the antral follicle count of the women in the two groups had decreased significantly after operation, and which of the women in group A were significant lower than those of the women in group B.The levels of serum LH and FSH of the women in the two groups had increased significantly after operation, and which of the women in were significant higher than those of the women in group B (P＜0.05).In group A, the serum CA199 level of the women was positively correlated with their serum HE4 level (r=0.322, P=0.001), and their CA199 level and HE4 level were positively correlated with their E2 level, but the CA199 level and HE4 level were negatively correlated with their levels of LH and FSH (P＜0.05). Conclusion: The levels of serum CA199 and HE4 of the women have decreased significantly after laparoscopic ovarian cyst resection, which are closely related to the changes of their sex hormone levels. So the levels of serum CA199 and HE4 can be used to predict the change of postoperative ovarian function of the women.
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