Abstract To compare the anesthesia quality and safety of general anesthesia combined with transverse abdominal muscle plane (TAP) nerve block during laparoscopic hysterectomy. Methods: 80 patients who wanted elective laparoscopic hysterectomy were selected and were divided into group A and group B (40 cases in each group) by random number table method from June 2018 to December 2020. The patients in group A received general anesthesia combined with ultrasound to guide bilateral TAP nerve block, and the patients in group B received intravenous inhalation combined with general anesthesia. The levels of adrenal hormone (AD), dopamine (DA), noradrenaline (NE), and the values of heart rate (HR), blood oxygen saturation (SpO2), and mean arterial pressure (MAP) of the patient in the two groups at 10min before anesthesia (T0), 10min after anesthesia (T1), beginning of surgery (T2), 10min after surgery (T3), 10min after extubation (T4) were detected. The VAS scores of patients in the two groups were recorded at 2h, 12h, and 24h after operation. The anesthesia recovery situation and adverse reactions rate of patients were compared between the two groups. Results: The AE, DA, and NE levels, and the HR, SpO2, and MAP values of the patients at T0, T1, T2 had no significant different between the two groups (P＞0.05). At T3 and T4, The AE, DA and NE levels of the patients in group A were significant lower than those of the patients in group B (P＜0.05). The AE, DA and NE levels of patients in the two groups at T3 were significant higher than those at other time point (P＜0.05). The HR and MAP values of the patients in group A at T3 and T4 were significant lower than those of patients in group B, but the SpO2 value of the patients in group A was significant higher (P＜0.05). The HR and MAP values of the patients in the two groups at T3 were significant higher than those at other time point, but the SpO2 value of the patients in the two groups at T3 was significant lower than that at other time point (P＜0.05). VAS scores of the patients in group A at postoperative 2h, 12h, and 24h were significant lower than those of the patients in group B. The recovery time of spontaneous breathing or waking time of the patients in group A was significant lower than that of the patients in group B, the incidences of adverse reactions, such as agitation, chills and tachycardia during wake period of the patients in group A were significant lower than that of the patients in group B (P＜0.05). There were no significant differences in the incidences of nausea and vomiting, dizziness, chest tightness, and hypotension of the patients between the two groups (P＞0.05). Conclusion: The general anesthesia combined with TAP nerve block during laparoscopic hysterectomy can not only effectively alleviate the influence of anesthesia and operation on the stress response of the patients, but also stabilize the hemodynamics of patients, and reduce the incidence of adverse reactions, which anesthesia quality and safety are superior to those of inhalation combined general anesthesia.
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