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Abstract To analyze the effect of low molecular heparin combined with ligustrazine for improving uterine arterial hemodynamics and the expressions of vascular endothelial injury factors of the pregnant women with preeclampsia (PE). Methods：147 pregnant women with PE were selected as study subjects from May 2017 to March 2020. According to the principle of random number, these women were divided into control group, group A, and group B. In the control group, the women were given conventional treatment. In the group A, the women were given low molecular heparin except to conventional treatment, and in the B group, the women were given low molecular heparin combined with ligustrazine except to conventional treatment. Results: 24h after treatment, urinary protein level of the women in the control group was the highest, which was followed by that of the women in group A, and which of the women in group B was the lowest (P＜0.001). There were no significant differences in the values of systolic and diastolic blood pressure of the women among the three groups (P＞0.05). The uterine artery RI value of the women in the control group was the highest, which was followed by that of the women in group A, and which of the women in group B was the lowest (P＜0.001). The values of uterine artery S/D and PI the women in group A and B had no significant different, but which were significant lower than those the women in the control group (P＜0.05). The levels of serum sEng, sFlt-1, and ET-1 of the women in the control group were the highest, which were followed by those of the women in group A, and which of the women in group B were the lowest (P＜0.001). The VEGF level of the women in the control group was the lowest, which was followed by that of the women in group A, and which of the women in group B was the highest (P＜0.001). The gestational age and the proportion of Apagar score ≥7 points of newborns in group B were significant higher than those of newborns in the other two groups (P＜0.05), but which had no significant different between the control group and group A. There were no significant differences in newborn birth weight and neonatal asphyxia rate among the three groups (P＞0.05). Conclusion: The effect of low molecular heparin combined with ligustrazine for improving uterine artery blood flow and vascular endothelial injury is better than that of low molecular heparin used alone, which can further prolong the gestational age and improve the perinatal outcome.
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