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| Analysis of the correlation between the serum Hcy and VB12 levels of the pregnant women with megaloblastic anemia during pregnancy and their prognosis |
| 1.The Second Hospital of Shaoxing, Zhejiang Province, 312000；2.Shaoxing Maternal and Child Health Care Hospital |
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Abstract To explore the correlation between the serum homocysteine (Hcy) and vitamin B12 (VB12) levels of the pregnant women with megaloblastic anemia (MA) during pregnancy and their prognosis. Methods: A total of 76 pregnant women with MA were selected in study group and 65 healthy pregnant women were selected in control group from January 2019 to June 2020. The general data, blood routine indexes, and serum Hcy and VB12 levels of the women were compared between the two groups. The women in the study group were divided into group A (31 women with good prognosis) and group B (45 women with bad prognosis) based on the results of the end of pregnancy. The main factors affecting the MA prognosis of the women were analyzed. Results: The levels of Hb, RBC, MCHC, and VB12 of the women in the study group were lower than those of the women in the control group, while the levels of MCV, MCH, and Hcy of the women in the study group were significant higher (P<0.05). Pearson's results showed that the serum VB12 level of the women in the study group was positively correlated with their levels of Hb, RBC and MCHC, and was negatively correlated with their levels of MCV and MCH. The serum Hcy level of the women in the study group was positively correlated with their levels of MCV and MCH, and was negatively correlated with their levels of VB12, Hb, RBC, and MCHC (all P<0.05). The levels of Hb, RBC, MCHC, and VB12 of the women in group B were significant lower than those of the women in group A, while the levels of MCV, MCH, and Hcy of the
women in group B were significant higher than those of the women in group A (all P<0.05). Multivariate logistic regression analysis showed that the levels of Hb, RBC, MCV, Hcy, and VB12 were the risk factors affecting the prognosis of the women with MA during pregnancy (P<0.05). Conclusion: The serum VB12 level of the pregnant women with MA decreases, but the Hcy level of them increases, which both are related to their blood routine index levels. The serum VB12 and Hcy levels are the risk factors affecting the prognosis of pregnant women with MA in clinic, which should be paid more attention to.
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