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| The correlation between the serum FABP-4, ADP, RBP4, Nesstatin-1 levels and insulin resistance in women with gestational diabetes mellitus and their diagnostic value |
| Hangzhou Hospital of Traditional Chinese Medicine, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang Province, 310007 |
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Abstract To explore the correlation between the serum FABP4, ADP, RBP-4, and Nesstatin-1 levels of the pregnant women with gestational diabetes mellitus (GDM) and their insulin resistance, and to study its diagnostic value. Methods: 50 pregnant women with GDM were selected in study group from September 2016 to December 2019, and another 50 pregnant women with normal glucose tolerance were selected in control group. The values of insulin resistance indicators and serum FABP-4, ADP, RBP4 and Nesstatin-1 levels of the women were compared between the two groups. The correlation between serum FABP-4, ADP, RBP4 and Nesstatin-1 levels of the women and their insulin resistance was analyzed. The predictive value of serum FABP-4, ADP, RBP4, and Nesstatin-1 levels for GDM was also analyzed. Results: The levels of C-peptide, fasting islet (FINS), and islet resistance index (HOMA-IR) of the women in the study group were significant higher than those of the women in the control group, but the function indexes of islet β cell (HOMA-β) of the women in the study group were significant lower than those of the women in control group. The levels of FABP-4, RBP4, and Nesfatin-1 of the women in the study group were significant higher than those of the women in the control group, and the level of ADP of the women in the study group was significant lower (all P<0.05). Spearman correlation results showed that serum FABP-4, RBP4, and Nesfatin-1 levels were positively correlated with HOMA-IR value, and which were negatively correlated with HOMA-β value. ADP level was negatively correlated with HOMA-IR value, and was positively correlated with HOMA-β value (all P<0.05). ROC curve analysis showed that serum FABP-4, ADP, RBP4, and Nesfatin-1 levels for diagnosing GDM had all high accuracy, which’s sensitivity and specificity were 94.0% and 80.0%, 92.0% and 90.0%, 90.0% and 90.0%, and 96.0% and 100.0%, respectively. AUC, the sensitivity, and the specificity of the combined serum FABP-4, ADP, RBP4, and Nesfatin-1 levels for diagnosing GDM were 1.000, 100.0%, and 100.0%, respectively. Conclusion: Serum FABP-4, ADP, RBP4, and Nesstatin-1 levels of pregnant women with GDM are closely related to their insulin resistance, and which have high predictive value for GDM, especially the combined serum FABP4, ADP, RBP4, and Nesfatin-1 levels has higher predictive value.
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