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| Application of non-elective sequential embryo transfer in thaw embryo transfer cycle of women with repeated implantation failure |
| Women and Children’s Hospital, School of Medicine, Xiamen University; Xiamen Maternal and Child Health Care Hospital; Xiamen Key Laboratory of Reproduction and Genetics, Fujian Province, 361000 |
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Abstract To explore the clinical pregnancy rate of non-elective sequential embryo transfer in thaw embryo transfer cycle of women with repeated implantation failure (RIF). Methods：1119 women with RIF who underwent IVF/ICSI-ET were analyzed retrospectively. The women were divided into three groups according to different types of embryos transfer, which included 100 women with non-elective sequential embryo transfer of D3 embryo and D5 or D6 blastaea in group A, 896 women with embryo transfer of D3 embryo in cleavage stage in group B, and 123 women with non-elective transfer of D3 blastaea in group C. The women in the three groups were all in thaw embryo transfer cycle, and two embryos were transferred for each woman. The general situation and the pregnancy outcomes of the women were analyzed and compared among the three groups. Results：The clinical pregnancy rate (49.0%) of the women in group A was statistically significant different from that (36.7%) of the women in group B (P<0.05). The implantation rates of the women in the three groups were 29.0%, 22.7%, and 28.5%, respectively, which of the women in group A was significant different from that of the women in group B, and which of the women in group B was significant different from that of the women in group C (P<0.05). There were no significant differences in the rates of live birth and abortion of the women among the three groups (P>0.05). Conclusion：Non-elective sequential embryo transfer of the women in thaw cycle can improve the pregnancy outcomes of the women with RIF, which can be regarded as an appropriate approach to improve embryo transfer success rate of the women with RIF.
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