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Abstract To analyze the influence of different doses of dexmedetomidine combined with oxycodone for analgesia of women after cesarean section on their analgesic effect and lactation. Methods: 162 pregnant women who wanted cesarean section were included as the research objects, and were divided into group A, B, and C (54 cases in each group) by random number table from January 2018 to December 2020. The women in group A, B, and C were treated with 0.3ug/kg.h, 0.4ug/kg.h, and 0.5ug/kg.h of dexmedetomidine combined with 0.4mg/kg oxycodone for postoperative analgesia, respectively. Ramsay sedation score (RSS) and visual analog pain score (VAS) at 30min (T0), 1h (T1), 2h (T2), 4h (T3), 8h (T4), 12h (T5), 24h (T8), and 48h (T7) after cesarean section of the women in the three groups were observed. The serum prolactin (PRL) level before and postoperative 24h, 48h, and 72h, the time of first lactation after cesarean section, and postoperative adverse reactions rate of the women were compared among the three groups. Results: As for sedative effect, Ramsay score of the women in group C, B and D at T0, T1, T2, T3, T4, T5, T6 and T7 had decreased in turn (P<0.05). As for analgesic effect, VAS scores of the women in group C and C at T0, T1, and T2 were significant lower than those of the women in group A (P<0.05), but VAS scores of the women at T3, T4, T5, T6, and T7 had no significant difference among the three groups (P>0.05). The serum PRL level and the first lactation time of the women in group C and B at 24h, 48h and 72h after surgery had no significant difference, but which were all significant higher than those of the women in group A (P<0.05). During analgesia, the incidences of nausea (14.0%), hypotension (13.0%), and bradycardia (16.7%) of the women in group A were significant higher than those of the women in the other two groups (P<0.05), but there were no significant differences in the incidences of vomiting, dizziness, and oversedation of the women among the three groups (P>0.05). Conclusion: 0.4ug/kg.h of dexmedetomidine combined with 0.4mg/kg of oxycodone for analgesia of women after cesarean section has exact effectiveness, which helps to increase the level of maternal postoperative serum prolactin, shorten the first lactation time, and reduce the incidence of adverse reactions with high safety in clinic.
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