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Abstract To explore the clinical effect of enteric-coated aspirin for treating pregnant women with threatened abortion and high D-dimer level. Methods: 160 pregnant women with threatened abortion were selected and were divided into control group and observation group (80 cases in each group) by the random number table between November 2019 and November 2020. On the basis of conventional fetal preservation treatment, the women in the control group were treated with low molecular heparin, and the women in the observation group were given low molecular heparin combined with enteric-coated aspirin tablets. The efficacy, levels of hormones, coagulation function, hemodynamic parameters, success rate of fetal preservation, and adverse reactions of the women were compared between the two groups. Results: After treatment, the total effective rate (92.5%) of the women in the observation group was significant higher than that (81.3%) of the women in the control group (P<0.05). After treatment, the levels of human chorionic gonadotropin, progesterone, and estradiol of the women in the two groups had increased significantly, the values of coagulation index, such as activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT) of the women in the two groups had prolonged significantly, and the values of fibrinogen (FIB), D-dimer, hemodynamic parameters resistance index (RI), and systolic/diastolic ratio (S/D) of the women in the two groups had decreased significantly (all P<0.05). There was no significant difference in pulse coefficient of the women in the two groups between before and after treatment (P>0.05). There was no any woman with serious adverse reaction in the two groups. Conclusion: Enteric-coated aspirin for treating pregnant women with threatened abortion and high D-dimer level has significant efficacy, which can relieve the hypercoagulable state and improve uterine hemodynamics index with better safety.
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