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| The relationship between vitamin D level during the first trimester of pregnancy and the occurrence of maternal gestational diabetes mellitus |
| Zhoukou Maternal and Child Care Health Hospital (Zhoukou Children's Hospital), Henan Province, 466000 |
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Abstract To analyze the relationship between maternal vitamin D (VD) level during the first trimester of pregnancy and the occurrence of maternal gestational diabetes mellitus (GDM). Methods: The clinical data and the results of oral glucose tolerance test (OGTT) of 1074 pregnant women during the first trimester of pregnancy from January 2018 to January 2020 were selected. The serum 25 (OH) D levels of these women were detected by chemiluminescence immunoassay. These women were divided into different groups according to their degree of VD deficiency. The blood glucose level and risk of GDM occurrence of the women were compared among these groups. Results: The serum 25(OH) D level of the women with GDM was significant lower than that of the women with normal blood glucose (P＜0.05). The blood glucose levels of fasting, OGTT 1h and OGTT 2h of the women with severe VD deficiency were significant higher than those of the women with mild VD deficiency and those of the women with normal VD. The blood glucose levels in OGTT 1h and OGTT 2h of the women with mild VD deficiency were significant higher than those of the women with normal VD (all P＜0.05). There was no significant difference in fasting blood glucose level between the women with mild VD deficiency and the women with normal VD (P＞0.05). The incidence of GDM of the women with normal VD, the women with mild VD deficiency, and the women with severe VD deficiency had increased gradually. The risk of GDM occurrence the women with mild or severe VD deficiency had increased, and which of the women with severe VD deficiency was the highest (all P＜0.05). The 25(OH) D level of the pregnant women had predictive efficiency for their GDM occurrence (P＜0.001, 95%CI 0.126-0.310). The incidence of 1 result of OGTT of the women with normal VD level, the women with mild VD deficiency, and the women with severe VD deficiency had de creased gradually. The incidence of 2 or 3 results of OGTT of the women with normal VD level, the women with mild VD deficiency, and the women with severe VD deficiency had increased gradually (P＜0.05). Conclusion: VD deficiency of the pregnant women during the first trimester of pregnancy may increase the risk of GDM occurrence, which has some predictive value for GDM, and is related to the abnormal types of OGTT results.
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