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| Correlation between serum estradiol and 25(OH)D levels of the women and the clinical outcomes after single frozen-thawed blastocyst transfer |
| Henan Provincial People's Hospital, Zhengzhou, Henan Province, 450003 |
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Abstract To explore the correlation between serum estradiol (E2), 25-OH vitamin D ［25(OH)D］ levels of the women and their clinical pregnancy outcome after single frozen-thawed blastocyst transfer (SFBT). Methods: The clinical data of 204 women who had received SFBT from June 2018 to July 2020 were analyzed retrospectively, and according to the clinical pregnancy outcomes, these women were divided into group A (107 women with clinical pregnancy) and group B (97 women without clinical pregnancy). The general data of the women were compared between the two groups. The level of serum E2 of the women was measured by microparticle chemiluminescence method, and the level of serum 25(OH) D of the women was determined by high performance liquid chromatography-tandem mass spectrometry. Logistic regression analysis was used to analyze the influencing factors of clinical pregnancy outcomes, and receiver operating characteristic (ROC) curve was used to analyze the predicting value of serum E2 and 25(OH) D levels for clinical pregnancy outcomes. Results: There were no significant differences in age, duration of infertility, body mass index, endometrial thickness, infertility type, and basal follicle stimulating hormone (bFSH) level of the women between the two groups (P＞0.05). The levels of serum E2 (544.92±108.63 pmol/L) and 25(OH) D (65.37±16.26 nmol/L) of the women in group A were significant higher than those (365.73±72.57 pmol/L and 41.65±10.44 nmol/L) of the women in group B (P＜0.05). The levels of serum E2 and 25(OH) D of the women were the protective factors affecting their clinical pregnancy outcomes (P＜0.05), but age of the women was the risk factor affecting their clinical pregnancy outcomes (P＜0.05). The area under the curve (AUC), the cutoff value, the sensitivity, and the specificity of the E2 level for predicting the clinical pregnancy outcomes of the women after SFBT were 0.892, 444.76 pmol/L, 89.7%, and 79.4%. The AUC, the cutoff value, the sensitivity, and the specificity of the 25(OH) D level for predicting the clinical pregnancy outcomes of the women after SFBT were 0.893, 52.72 nmol/L, 88.7%, and 78.5%, respectively. And the AUC, the sensitivity, and the specificity of combinational E2 and 25 (OH) D levels for predicting the clinical pregnancy outcomes of the women after SFBT were 0.949, 87.6%, and 93.5%, respectively. Conclusion: The levels of serum E2 and 25(OH) D of the women without pregnancy after SFBT are low, which may affect the clinical pregnancy outcomes of the women after SFBT. The combination of the detected levels of E2 and 25(OH) D of the women after SFBT can improve the predictive value for clinical pregnancy outcomes.
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