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| Association human leukocyte antigen-G and maternal-fetal immunotolerance |
| 1.The Fourth Affiliated Hospital of Zhejiang University, Yiwu, Zhejiang Province, 322300； 2. The Affiliated Women’s Hospital of Zhejiang University |
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Abstract The major human histocompatibility antigen complex is called human leukocyte antigen (HLA). Human leukocyte antigen-G (HLA-G) is the most closely related non-classical HLA-Ib molecule with pregnancy. HLA-G low polymorphism is restriction distribution in maternal fetal interface of extravillous trophoblast and other immune tissues. The role of HLA-G in immune tolerance may be related to the change of endometrial natural killer cell (NK) activity. The change of HLA-G expression level is closely related to implantation, growth and development of the embryo, pregnancy outcomes after in vitro fertilization, normal pregnancy maintenance, and occurrence and development of pathological pregnancy (such as unexplained recurrent spontaneous abortion, preeclampsia, fetal growth restriction, premature rupture of membranes, and oligohydramnios). The research of the role of HLA-G in maternal-fetal immunity may have high clinical value for the prediction, prevention, and treatment of pathological pregnancy.
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