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| Effect of group B streptococcus infection during pregnancy on premature rupture of membranes and neonates and drug sensitivity |
| Jiangning hospital of Nanjing, Jiangsu Province, 211100 |
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Abstract To explore the effect of group B streptococcus (GBS) infection of women during pregnancy on premature rupture of membranes and neonates, and to study drug sensitivity. Methods: 1266 pregnant women who had received GBS screening were enrolled in this study from January 2018 to August 2018, and which included 220 women with premature rupture of membranes in observation group and 1046 women without premature rupture in control group. The detection result of GBS and neonatal outcomes were compared between the two groups. In addition, anti-infection intervention was given the women in the observation group. Results: The positive rate of GBS (12.3%) of the women in the observation group was significant higher than that (5.5%) of the women in the control group. The rates of premature rupture of membranes, puerperal infection, intrauterine infection, postpartum hemorrhage, and other adverse pregnancy of 85 women with GBS infection were significant higher than those of 1181 women without GBS infection. The total incidence (neonatal infection, fetal distress, neonatal asphyxia, and pneumonia of newborn) of the women with GBS infection (23.5%) was significant higher than that (8.8%) of the women without GBS infection. The neonatal Apgar score 1 min and 5 min after born (7.0±0.8 points, 8.4±1.7) of the women with GBS infection were significant lower than those (8.2±1.3 points and 9.0±2.0 points) of the women without GBS infection (all P＜0.05). The results of drug sensitivity test of the women with GBS infection showed that penicillin (95.3%) and cephalosporin (91.8%) were more sensitive, while clindamycin (72.9%) and amikacin (70.6%) were less sensitive. After nursing intervention, the satisfaction of the women with GBS infection was 100%. Conclusion: GBS infection of the women during pregnancy will increase the risk of neonatal adverse events and premature rupture of membranes. Therefore, drug sensitivity test should be performed immediately after the diagnosis of pregnant women infection, and targeted antibiotics treatment and nursing intervention should be selected for reducing the incidence of premature rupture of membranes, so as to improve the adverse outcomes of mothers and infants.
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