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| Relationship between the levels of serum CRP, NLR, PAF, FFN of the pregnant women with hypothyroidism and the preterm delivery occurrence |
| Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201210 |
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Abstract To investigate the relationship between the levels of serum C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), fetal fibronectin (FFN), platelet activating factor (PAF) of the pregnant women with hypothyroidism and the preterm delivery occurrence. Methods: 151 pregnant women with hypothyroidism were enrolled in observation group and 120 healthy pregnant women were enrolled in control group from January 2018 to January 2019. The levels of CRP, NLR, FFN and PAF of the women during the 28th gestational week were measured and were compared between the two groups. In the observation group, there were 46 women with preterm delivery in group A and 105 women without preterm delivery in group B. Logistic regression was used to analyze the factors affecting preterm delivery of the pregnant women with hypothyroidism. Results: The serum levels of CRP (8.86±2.31 mg/L), NLR (4.36±1.28), FFN (40.51±6.51 ng/ml) and PAF (2.89±0.55 ng/ml) of the women in the observation group were significant higher than those (5.14±1.66 mg/L, 1.77±0.53, 28.66±4.49 ng/ml, and 2.03±0.27 ng/ml) of the women in the control group (P＜0.05). Increase of age, vaginitis, cervix shortening, high levels of serum CRP, NLR, FFN and PAF were the independent risk factors of preterm delivery of the pregnant women with hypothyroidism (P＜0.05). Conclusion: The levels of serum CRP, NLR, PAF and fFN of the pregnant women with hypothyroidism increase significantly, and the high levels of which are the independent risk factors affecting their preterm delivery occurrence.
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