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| Value of thromboelastogram combined with five items of coagulation function for evaluating improvement of coagulation after low molecular weight heparin treatment of the women with severe preeclampsia |
| Qingdao Women's and Whildren's Hospital, Shandong Province, 266000 |
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Abstract To explore the value of thromboelastogram (TEG) combined with five items of coagulation function for evaluating improvement of coagulation after low molecular weight heparin treatment of the women with severe preeclampsia. Methods: 120 pregnant women with severe preeclampsia were selected and were randomly divided into group A and group B (60 cases in each group) from January 2019 to December 2019. The women in group A were given routine treatment (such as spasmolysis, hypotension, sedation, dilatation, and diuresis) for 3-5 days. The women in Group B were given subcutaneous injection of 5000U of low molecular weight heparin every day except to the treatment in the control group for 3-5 days. In addition, 60 pregnant women were selected in control group during the same time. The five items of coagulation function (PT, APTT, TT, Fib, and D-Dimer) and TEG parameters of the women before and after treatment were compared between group A and B. Results: The values of PT, TT, and APTT, and the values of R and K of TEG of the women in group A and B were significant lower than those of the women in the control group, but the values of FIB, D-D, and the values of α angle, MA, and CI of TEG of the women in group A and B were significant higher than those of the women in the control group (all P＜0.05). There were no significant differences in the five items of coagulation function and TEG parameters of the women between group A and B (P＞0.05). Compared with those before treatment, the values of PT, TT and APTT of the women after treatment in group A and B had increased significantly, the values of their FIB and D-D had decreased significantly, the values of their R and K values of TEG had increased significantly, and the values of their α Angle, MA and CI of TEG had decreased significantly (all P <0.05). After treatment, the values of PT and TT of the women in group B were significant higher than those of the women in group A, and D-D value of the women in group B was significant lower than that of the women in group A (all P＜0.05). There were no significant differences in APTT and FIB values of the women between group A and B (P＞0.05). The values of R and K of the women in group B were significant higher than those of the women in group A, but the values of α Angle, MA, and CI of TEG of the women in group B were significant lower (all P＜0.05). Conclusion: TEG used for evaluating the improvement of coagulation function after low molecular weight heparin treatment of the women with severe preeclampsia is better than that of five items of coagulation function, which suggests that TEG can be used as a testing method to evaluate coagulation function of the women with severe preeclampsia.
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