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| Study on the HPV typing of the women with cervical cancer and the relationship of the expressions levels of serum HMGA1and HE4 and their prognosis |
| 1.Henan University of science and technology, Luoyang, Henan Province, 471000；2. The First Affiliated Hospital of Henan University of science and technology |
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Abstract To explore the HPV typing of the women with cervical cancer, and to study the relationship of the expressions levels of serum high mobility protein A1 (HMGA 1) and human epididymal protein 4 (HE 4) and the prognosis of the women. Methods: 105 women with cervical cancer were selected in study group from August 2012 to September 2018. And 110 healthy women who underwent physical examination were selected in control group during the same period. The differentiation and correlation of serum HMGA 1 and HE 4 level with the prognosis of the women with cervical cancer were analyzed. Results: The serum HMGA 1 level (168.87±18.09ng/mL) and HE4 level (137.18±66.43 pmol/L) of the women in the study group were significant higher than those (109.74±13.84 ng/mL and 47.85±10.22 pmol/L) of the women in the control group (P<0.05). There were no significant difference in the levels of serum HMGA 1 and HE 4 among the women with different pathological types of cervical cancer (P>0.05), but which had significant differences among the women with different FIGO stage, among the women with different degree of differentiation, and the women with different lymphatic metastasis (P<0.05). HPV infection was detected in 105 (93.3%) women with cervical cancer, and among which, HPV 16 infection rate was 72.8% and HPV 18 infection rate was 10.5%. Univariate analysis showed that there were significant differences in the prognosis of the women with different ages, pathological stages, infiltration depth, lymphatic metastasis, cervical canal diameter, uterine involvement, or clinical stages (P<0.05). Cox regression analysis showed that tumor differentiation, lymphatic metastasis, and FIGO stage of the women were the independent risk factors affecting their prognosis. Conclusion: HPV typing and the serum HMGA 1 and HE4 levels of the women are associated with their cervical cancer occurrence, and tumor differentiation, lymphatic metastasis, and FIGO stage of the women with cervical cancer are the independent risk factors affecting their prognosis.
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