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| Thromboelastography manifestations of pregnant women with early recurrent spontaneous abortion and different number of abortion times and its correlation with pregnancy loss |
| The First People’s Hospital of Yongkang, Zhejiang Province, 321300 |
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Abstract To explore the thromboelastography (TEG) performance of pregnant women with early recurrent spontaneous abortion (RSA) and different abortion times, and to study its correlation with the pregnancy loss of the women. Methods: 119 pregnant women with early RSA were collected in group A from April 2019 to January 2020, and according to their abortion times, these women were divided into group A1 (28 women with≥4 times abortion), group A2 (54 women with 3 times abortion), and group A3 (37 women with 2 times abortion). Another 138 healthy pregnant women were selected in group B during the same period. TEG parameters of the women were compared between group A and group B, among group A1, A2, and A3, and among the women with different pregnancy outcomes. Results: The R and K values of the women in group A were significant lower than those of the women in group B, but the values of α angle, MA, and CI of the women in group A were significant higher (P<0.05). The MA value of the women in A1 group was significant higher than that of the women in group A2 and A3 (P<0.05), and there were no significant differences in R, K, α Angle and CI values of the women among group A1, A2 and A3 (all P>0.05). The pregnancy loss rate of the women in group A1 (39.3%, 11/28) was significant higher than that (18.5%, 10/54) of the women in group A2 and that (10.8%, 4/37) of the women in group A3 (P<0.05). The MA value of women with pregnancy loss was significant higher than that of normal pregnant women (P<0.05). The R, K, α Angle and CI values of women with different pregnancy outcomes had no significant different (P>0.05). The area under ROC curve of MA value for predicting pregnancy loss of the women with RSA was 0.723 (95%CI: 0.604-0.843). When the optimal cutoff point was 68.37, the sensitivity and the specificity were 76.4% and 71.4%. Conclusion: The values of R, K, αangle, MA, and CI in TEG of pregnant women with early RSA are abnormal, and the more the number of abortions, the higher the pregnancy loss rate and the more obvious the MA value increasing, so the MA value has a certain predictive value for pregnancy loss.
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