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Abstract To investigate the correlation between free thyroxine (FT4) level of the pregnant women during the first trimester of pregnancy and their occurrence of gestational diabetes mellitus (GDM). Methods: 200 pregnant women with GDM diagnosed by OGTT during 24-28 gestational weeks were retrospectively collected in study group, and 200 pregnant women with normal glucose tolerance were selected in control group. The FT4 levels of the women in the two groups were measured during 8-15 gestational weeks. The general clinical data and laboratory results of the women in the two groups were collected. Risk factors affecting the occurrence of GDM of these women were analyzed. And the value of maternal FT4 level for predicting GDM onset was analyzed by ROC curve. Results: The FT4 level (1.21±0.19ng/ml) of the women in the study group during 8-15 gestational weeks was significant lower than that (1.29±0.18ng/ml) of the women in the control group, and there were significant differences in age, pre-pregnancy body mass index (BMI), weight change during pregnancy, and the levels of fasting blood glucose (FPG), HbA1c, and total cholesterol (TC) of the women between the two groups (all P<0.05), but there were no significant differences in gestational times, birth times, the values of white blood cell (WBC) and red blood cell (RBC), and the levels of platelet (PLT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and triglyceride (TG) of the women between the two groups (P>0.05). The logistic regression analysis had showed that advanced age, higher BMI before pregnancy, greater variation of weight during pregnancy, higher levels of FPG, HbA1c, and TC, and lower FT4 level during 8-15 gestational weeks were all independent risk factors of the occurrence of GDM (P<0.05). ROC curve showed that the cutoff value of maternal FT4 level during 8-15 gestational weeks for predicting their occurrence of GDM was 1.235 ng/ml, and the AUC was 0.756 (95%CI 0.710-0.802), which’s sensitivity and specificity were 68.0% of 67.5%. Conclusion: Lower level of FT4 of pregnant women during 8-15 gestational weeks is one of the independent risk factors of their occurrence of GDM, which has some value for predicting the occurrence of GDM during the first trimester of pregnancy.
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