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| Clinical features analysis of pregnant women with Listeria monocytogenes infection |
| Xuanwu Hospital, Capital Medical University, Beijing, 100053 |
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Abstract To investigate the clinical features and pregnancy outcomes of pregnant women with Listeria monocytogenes (LM) infection during pregnancy. Methods: The clinical data of 7 pregnant women with LM infection during pregnancy from 2016 to 2018 were retrospectively analyzed. The clinical characteristics, laboratory diagnosis basis, antibiotic treatment, drug resistance, fetal condition, and pregnancy outcomes of the 7 pregnant women were analyzed. Results: The average age of these 7 pregnant women was 27.14 years old, and their average gestational week was 25.64 weeks. 1 pregnant woman (No.3 pregnant woman) was cured and discharged, and the remaining 6 fetus died in uterus. Among the 7 women, 6 (85.71%) women had fever and abnormal fetal movement. Among the 7 women, there were 4 women with high fever (1 woman with moderate fever), and 1 woman without fever. The white blood cell count and C-reactive protein level of No.3 pregnant woman with amniotic fluid pollution grade I were lower than those of other 6 pregnant women with amniotic fluid pollution degree Ⅲ. The samples from amniotic fluid and blood after LM culture all showed positive results. There was no any woman with premature rupture of fetal membranes in the 7 women. Only 1 case did not undergo histopathological examination due to inexperienced clinician, while the other 6 women had acute chorioamnionitis after histopathological examination, and among them, 1 woman had also acute omphalitis during the same time. The temperature of that discharged pregnant women returned to normal 2 days before discharge. There were 6 pregnant women with fetal death. There was 1 woman with postpartum infection in the 7 women. In the7 women, the body temperature of 4 cases returned to normal on the day of postpartum, and the body temperature of 2 cases returned to normal on the second day after delivery. The main treatment drugs were amoxicillin, cephalosporins, and meropenem. Conclusion: The clinical features of pregnant women with LM infection during pregnancy are mainly gastrointestinal reaction, cold like symptoms, and abnormal fetal movement. Antibacterial drugs are mainly used for treatment. LM infection does little harm to pregnant women, but it is easy to cause fetal death.
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