To compare the effect of focal excision repair (FER) combined with endoscopic uterine artery blockage（UAB）or uterine artery embolization (UAE) for treating women with uterine scar pregnancy (CSP), and to study the influencing factors of curative effect. Methods: The clinical data of 112 women with CSP from June 2018 to October 2019 were collected retrospectively, and these women were divided into group A (60 women with FER and UAE) and group B (52 women with FER and UAB). The treatment effects of women in the two groups were compared, and non-conditional binary classification Logistic regression analysis was used to analyze the influencing factors of curative effect. Results: There was no significant difference in the treatment success rate of women (93.3% vs. 96.2%) between the two groups (P=0.508). There were no significant differences in intraoperative blood loss, bloodβ-human chorionic gonadin (β-HCG) level, and the time of menstrual recovery of women between the two groups (P＞0.05). The time and cost of hospitalization of women in group B was significant lower than that of women in group A (P＜0.05). The multivariate analysis showed that gestational weeks, CSP type, and gestational sac volume by ultrasound were independent influencing factors of the curative efficacy of CSP (P＜0.05). Conclusion: Laparoscopic temporary uterine artery blockage is an effective, safe, less complication, and economical pretreatment method for lesions excision, which can replace UAE in non-emergency situation. The gestational weeks, the type of CSP, and the gestational sac volume by ultrasound are independent factors of curative effect of CSP. In the clinic, targeted treatment measures should be focused on these influencing factors for improving curative efficacy.