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| Effect of epirubicin injection combined with megestrol acetate tablets on the levels of tumor markers and related protein of women with endometrial carcinoma |
| Hubei Integrated traditional Chinese and Western Medicine Hospital, Wuhan, Hubei Province, 430015 |
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Abstract To investigate the effect of epirubicin injection combined with megestrol tablets on the levels of tumor markers and related proteins of women with endometrial carcinoma. Methods: 90 patients with endometrial cancer were enrolled and were divided into observation group (50 cases) and control group (40 cases) according to their choice of treatment plan. The patients in the control group were treated with megestrol tablets orally, and the patients in the observation group were given epirubicin injection combined with megestrol tablets. The changes of the sex hormones levels, and tumor markers and related protein levels of the patients were compared between the two groups before and after treatment. Results: At the end of treatment, there was no significant change in the testosterone level of the patients in the two groups (P＞0.05), but the levels of follicle stimulating hormone, progesterone, estradiol, luteinized hormone, human epididymal epithelial secreted protein 4, CEA, carbohydrate antigen 125, tumor-related protein PCNA, and Bcl-2 had decreased significantly, and the levels of level of Bax protein had increased significantly, the changes of the patients in the observation group was significant more than that those of the patients in the control group (all P＜0.05). The total effective rate of the patients in the observation group (82.0%) was significant higher than that (62.5%) of the patients in the control group, but the incidence of adverse reactions of the patients in the observation group (30.0%) was significant lower than that (57.5%) of the patients in the control group (all P＜0.05). Conclusion: Epirubicin injection combined with megestrol tablets for treating patients with endometrial cancer has high effect, which can effectively improve the quality of life and reduce the adverse reaction of patients, so it has certain clinical application value.
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