|
Abstract To investigate the value of detection of plasma thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin complex (PIC), thrombomodulin (TM), tissuetype plasminogen activator-inhibitor complex (tPAI-C) for predicting deep venous thrombosis (DVT) of women during the second and third trimester of pregnancy. Methods：48 women with DVT during the second and third trimester of pregnancy were enrolled in study group, and 54 normal pregnant women during the second and third trimester of pregnancy were enrolled in control group from January 2019 to September 2019. The baseline data and the levels of TAT, PIC, TM, and tPAI-C of women were compared between the two groups. The independent influencing factors of DVT were analyzed by multivariate regression analysis. The ROC curve was used to determine the best cutoff point and prediction efficiency. Results：In the study group, PLT level of women during the third trimester of pregnancy was significant lower than that of women during the second trimester of pregnancy, but the levels of FIB, PT, TAT, PIC, TM, and TPAI-C of women during the third trimester of pregnancy were significant higher (P＜0.05). There were no significant different in the levels of PLT, FIB, PT, TAT, PIC, TM, and TPAI-C of women in the control group between the second and the third trimester of pregnancy (P＞0.05). The FIB and PT levels of women in the study group during the second and third trimester of pregnancy were significant lower than those of women in the control group, while the levels of TAT, PIC, TM and TPAI-C were significant higher (all P＞0.05). TAT level, PIC level, TM level, and TPAI-C level were independent influencing factors of DVT occurrence of women during the second and third trimester of pregnancy (P＜0.05). The value of combined detection of PIC, TM and TPAI-C for predicting DVT of women during the second and third trimester of pregnancy was the highest (P＜0.05). Conclusion: TAT level, PIC level, TM level, and TPAI-C level are independent influencing factors of DVT occurrence of women during the second and third trimester of pregnancy, and combined detection of the levels of TAT, PIC, TM, and TPAI-C can provide evidence for early clinical diagnosis and treatment of DVT of pregnant women.
|
