Abstract To observe the clinical efficacy of Qingrefumo decoction for treating women with chronic endometritis (CE), and to investigate its mechanism. Methods: 70 women with CE were selected and were randomly divided into observation group (35 cases) and control group (35 cases) by random number table. The women in the control group were given conventional medicine treatment, and the women in the observation group were given Qingrefumo decoction except to conventional medicine treatment. The efficacy of women was compared between the two groups. The changes of the serum levels of tumor necrosis factor-α(TNF-α), interleukin (IL)-1β, IL-4, IL-6, IL-10, IL-17, transforming growth factor-β1 (TGF-β1), matrix metalloproteinase-9 (MMP-9), vascular cell adhesion molecule (VCAM-1), malondialdehyde (MDA), advanced oxidized protein product (AOPP), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) of women in the two groups were measured. Results: There was no significant difference in the total effective rate of women (97.1% vs. 91.4%) between the two groups (P＞0.05). The rate of recovery or efficiency of women in the observation group (85.7%) was significant higher than that (71.4%) of women in the control group (P＜0.05). During the second, third and fourth course of treatment, TCM syndrome scores of women in the observation group were all significant lower than those of women in the control group (P＜0.05). The levels of serum TNF-α, IL-1β, IL-6, IL-17, MMP-9, VCAM-1, MDA, and AOPP of women in the observation group were all significant lower than those of women in the control group, while the levels of serum IL-4, IL-10, TGF-β1, SOD, and GSH-Px were significant higher than those of women in the control group (P＜0.05). 6 months after followed up, the recurrence rate of women in the observation group (6.7%) was significant lower than that (28.0%) of women in the control group (P＜0.05), and there was no significant difference in the rate of adverse reaction of women (11.4% vs. 8.6%) between the two groups. Conclusion: Qingrefumo decoction for treating women with CE can improve the clinical efficacy and reduce recurrence rate, which’s mechanism may be related to the inhibition of inflammation and oxidative damage.
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