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| Analysis of the correlation between recurrent spontaneous abortion and sperm malformation rate and DNA integrity |
| 1.Baoji Maternal and Child Health Care Hospital, Shaanxi Province, 721000; 2. Reproductive Medicine Center Xingyuan Hospital |
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Abstract To analyze the correlation between recurrent spontaneous abortion and sperm deformity rate and DNA integrity. Methods: 150 men with recurrent spontaneous abortion history of their wives were enrolled in the experimental group from June 2015 to June 2019, and 150 men without recurrent spontaneous abortion history of their wives were selected in the control group during the same period. The semen quality of the men was compared between the two groups. The correlation between recurrent abortion and their sperm deformity rate and DNA integrity was analyzed. Results: The sperm motility, A-grade percentage, sperm concentration, and forward-moving sperm rate of the men in the experimental group were significant lower than those of the men in the control group, but the deformity rates of sperm heads and tails, and DNA fragmentation index (DFI) of sperm of the men in the experimental group were significant higher (P＜0.05). Spearman correlation data analysis had showed that sperm deformity rate and DFI were positively correlated with the recurrent miscarriage. Conclusion: Recurrent abortion of women is closely related to the sperm deformity rate and DNA integrity of their husbands. Improving sperm quality of the husbands of women can effectively prevent recurrent spontaneous abortion.
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