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| Influence of laparoscopy combined with leuprolide acetate for treating infertility women with endometriosis on their pregnancy outcomes |
| Guang'an People's Hospital, Sichuan Province, 638000 |
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Abstract To investigate the influence of laparoscopy combined with leuprolide acetate for treating infertility women with endometriosis (EMS) on their pregnancy outcomes. Methods: 80 infertility women with endometriosis were selected and were divided in to study group and control group (40 cases in each group) between March 2017 and March 2019. The women in the study group were given laparoscopic treatment combined with leuprolide acetate, and the women in the control group were given laparoscopic treatment. The clinical efficacy, the scores of menopausal symptoms (Kupperman), VAS score of pelvic pain, the level of serological indicator, and the rates of recurrence and pregnancy within 1 year of women were compared between the two groups. Results: The effective rate of women in the study group (95.0％) was significant higher than that (67.5%) of women in the control group. The scores of Kupperman and VAS of women in the study group (5.80±2.11 points and 1.59±0.22 points) were significant lower than those (8.52±3.84 points and 2.04±0.51 points) of women in the control group. The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), serum matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), human epididymis protein (HEP), carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199) of women in the study group were significant lower than those of women in the control group. The recurrence rate of women within 1 year in the study group (5.0%) was significant lower than that (25.0%) of women in the control group. The pregnancy rate of women within 1-year in the study group (45.0%) was significant higher than that (20.0%) of women in the control group (P＜0.05). Conclusion: Laparoscopy combined with leuprolide acetate for treating infertility women with endometriosis has high effectiveness, which can relieve clinical symptoms and pain, improve sex hormone levels, reduce the rate of recurrence, and increase the pregnancy rate.
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