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| Correlation analysis of blood flow resistance index by Doppler ultrasound and the levels of serum ANGPTL4 and Ang-2 in women with ovarian tumor |
| Liaocheng People's Hospital, Shandong province, 252000 |
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Abstract To investigate the correlations between the blood flow resistance index (RI) by Doppler ultrasound and the levels of serum angiopoietin-like protein 4 (ANGPTL4) and angiotensin-2 (Ang-2) of women with ovarian cancer. Methods: From October 2016 to October 2019, 84 women with ovarian tumors were collected in the study group, which included 23 women with benign tumors, 28 women with borderline tumors, and 33 women with malignant tumors based on the pathological results. In addition, 85 healthy women were selected in control group during the same period. The blood flow resistance index (RI) value of women in the two groups was detected by Doppler ultrasound, and the serum ANGPTL4 and Ang-2 levels were detected by ELISA. Pearson's method was used to analyze the correlation between RI value and ANGPTL4 level or Ang-2 level, and between ANGPTL4 level and Ang-2 level in the study group. Spearman method was used to analyze the relationship between the levels of RI, ANGPTL4 and Ang-2 levels of women and their benign and malignant diseases in the study group. The RI value (0.50±0.08) of women in the study group was significant lower than that (0.63±0.12) of women in the control group, but the serum of ANGPTL4 level (52.29±8.91 ng/ml) and Ang-2 level (32.48±5.17 ng/ml) of women in the study group were significant higher. RI value of women with benign tumor, with borderline tumor, and with malignant tumor were 0.63±0.09, 0.54±0.07, and 0.37±0.06, respectively, which had decreased in turn, while the serum levels of ANGPTL4 and Ang-2 increased in turn (P＜0.05). RI value of women with ovarian tumor was negatively correlated with the levels of ANGPTL4 and Ang-2. And RI value was negatively correlated with benign and malignant diseases, but serum ANGPTL4 and Ang-2 levels were positively correlated with benign and malignant diseases (all P＜0.05). Conclusion: The RI value is closely related to the levels of serum ANGPTL4 and Ang-2, and the tumor benign and malignant, which has some reference value of clinical diagnose and therapy.
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