To investigate the relationship between preoperative miR-376c-3p level and the clinic pathological features of cervical cancer, and to study its predictive value for postoperative recurrence. Methods: 90 women with cervical cancer underwent radical surgery during January 2012 to January 2015 were selected in study group, and 100 women with cervical erosion were in control group. The preoperative miR-376c-3p expression level in cervical lesion biopsy samples of women were compared between two groups. The relationship between the level of mir-376c-3p of women with cervical cancer and their clinic pathological characteristics were analyzed. Further, the women with cervical cancer were divided into group A (45 women with high miR-376c-3p level ) and group B (45 women with low miR-376c-3p level ) according to the median expression level of miR-376c-3p. Kaplan-Meier survival curve was used to analyze the survival status of women, and ROC curve was used to analyze the value of preoperative miR-376c-3p level for predicting postoperative recurrence of women with cervical cancer. Results: Expression level of miR-376c-3p in cervical tissue of preoperative lesion biopsy of women in the study group was significant lower than that of women in the control group (P＜0.05). In the study group, there was significant different in the preoperative expression level of miR-376c-3p among women with different tumor maximum diameter, FIGO stage, lymph node metastasis, and interstitial infiltration depth (P＜0.05), but there was no significant difference in preoperative expression level of miR-376c-3p among women with different ages, menstrual states, and pathological types (P＞0.05). KaplanMeier survival curve showed that relapse-free survival of women in group A was significant better than that of women in group B (P＜0.05). For predicting postoperative recurrence, ROC curve found that the postoperative recurrence cut-off point, the area under the curve, the sensitivity, and the specificity were  0.625, 0.688 (95%CI: 0.544-0.833), 52.6%, and 78.6%, respectively. Conclusion: The expression of miR-376c-3p level in cervical cancer tissues is abnormal low, which is relationship with clinic pathological characteristics, and has certain value for evaluating the relapse-free survival and predicting postoperative recurrence.