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| Effect of ropivacaine combined with epidural anesthesia of dexmedetomidine used during caesarean section on the maternal stress response and neonatal Apgar score |
| Jiangyou People's Hospital, Jiangyou, Sichuan Province, 621700; 2. Guang 'an People's Hospital of Sichuan Province |
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Abstract To analyze the effect of ropivacaine combined with epidural anesthesia of dexmedetomidine used during caesarean section on maternal stress response and neonatal Agar score. Methods: The clinical data of 82 puerperae with cesarean section from January 2018 to January 2020 were analyzed retrospectively. According to different anesthesia methods, they were divided into observation group and control group (41 cases in each group). Women in the control group were treated with epidural anesthesia of dexmedetomidine, and women in the observation group were treated with epidural anesthesia of dexmedetomidine combined with ropivacaine. The maternal stress response, wake-up time, the time of spontaneous urination, and adverse reactions, and newborn Apgar score were compared between the two groups. Results: There were no significant differences in the levels of maternal stress response indexes, such as superoxide dismutase(SOD), plasma cortisol (Cor), serum malonaldehyde (MDA), and endothelin (ET) of women before anesthesia and 1 h after anesthesia between the two groups (P>0.05), however, at the T1, the levels of SOD, Cor, MDA and ET when anesthesia begin of women in the observation group were significant lower than those of women in the control group (P<0.05). The neonatal Apgar score in the observation group was 8.37±1.30 points, which had no significant different from that (8.35±1.31 points) in the control group (P>0.05). The time of wakefulness and the time of voluntary urination of women in the observation group were 19.03±3.12 min and 2.01±0.20 h, which were significant shorter than those (26.44±2.13 min and 2.98±0.36 h) of women in the control group (P<0.05). There were no significant different in the rates of nausea, vomiting, headache, hypotension, and bradycardia occurred of women between the two groups (P>0.05). The incidence of chills of women in observation group was 2.4%, which was significant lower than that (26.8%) of women in the control group (P<0.05). Conclusion: Ropivacaine combined with epidural anesthesia of dexmedetomidine can reduce maternal stress response, reduce the incidence of postoperative chills, and has no significant side effect on newborns.
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