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| Analysis of the treatment status and adverse pregnancy outcomes of pregnant women with syphilis infection in Zhejiang region |
| 1. Xixi Hospital, Hangzhou, Zhejiang Province, 310024；2. The Fourth Affiliated Hospital of Zhejiang University School of Medical |
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Abstract To investigate the treatment status of pregnant women with syphilis infection in Zhejiang province, and to analyze the risk factors of adverse pregnancy outcomes. Methods: A total of 406 pregnant women with syphilis infection registered in syphilis surveillance system of pregnancy in Zhejiang province from May 2015 to December 2018 were studied prospectively, and 319 women were followed up to delivery. The treatment situation during pregnancy of women with syphilis infection was analyzed. Logistic regression model was used to analyze the risk factors of adverse pregnancy outcomes. Results: Among the 319 pregnant women with syphilis infection, 194 women were treated their syphilis infection, and the treatment rate was 60.82%. 112 (35.11%) women had received standardized treatment. The treatment proportion of women with higher education level (bachelor degree or above), of women inservice, and primipara was significant higher (P＜0.05). The proportion of adverse pregnancy outcomes of these women with without treatment, or with initial RPR titer ≥ 1:16 was significant higher (P＜0.05). Logistic regression analysis showed that initial RPR titer ≥ 1:16, diagnosed as advanced stage of syphilis infection, and syphilis infection diagnosed during the third trimester of pregnancy were the independent risk factors of adverse pregnancy outcomes of women with syphilis infection (P＜0.05), but standardized treatment was a protective factor (P＜0.05). Conclusion: In this survey, the treatment compliance of pregnant women with syphilis infection is affected by education level, occupation, pregnancy and childbirth history. The incidence of adverse pregnancy outcomes of pregnant women with syphilis infection was high, and the diagnosis time of syphilis infection, syphilis stage, treatment status, and RPR titer of initial examination were correlated with pregnancy outcomes.
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