|
|
|
| The expression of miR-375 in peripheral blood of pregnant women with gestational diabetes mellitus during the second trimester of pregnancy and its value for predicting postpartum abnormal glucose metabolism |
| Shajing People's Hospital of Baoan district, Shenzhen, 518104 |
|
|
|
Abstract To investigate the expression of miR-375 in peripheral blood of pregnant women with gestational diabetes mellitus (GDM) during the second trimester of pregnancy, and to study its value for predicting postpartum abnormal glucose metabolism. Methods: The date of 200 pregnant women with GDM during the second trimester of pregnancy underwent pregnancy from January 2018 to July 2019 were collected retrospectively and were included in study group, another 100 normal pregnant women were in control group. The differentiation of miR-375 level in peripheral blood of women was compared between the two groups. According to the occurrence of postpartum abnormal glucose metabolism, the women in the study group were divided into group A (139 women with postpartum normal glucose metabolism) and group B (61 women with postpartum abnormal glucose metabolism). The influencing factors of postpartum glucose metabolism abnormality were analyzed. The value of miR-375 expression level in peripheral blood for predicting abnormal postpartum glucose metabolism was analyzed by ROC. Results: The level of miR-375 of women in the study group was significant higher than that of women in the control group, and there were statistically significant differences in preconception body mass index (BMI), pregnancy weight gain, family history of diabetes, and miR-375 level of women between two groups(all P＜0.05). Logistic regression analysis showed that higher pre-pregnancy BMI, more weight gain during pregnancy, family history of diabetes, and higher miR-375 level were the risk factors of postpartum abnormal glucose metabolism of women with GDM (P＜0.05). ROC curve showed that critical value, the sensitivity, the specificity, and AUC of peripheral blood miR-375 level for predicting postpartum abnormal glucose metabolism of women with GDM were 0.625, 64.03%, 78.69%, and 0.760（95%CI 0.691-0.829）, respectively. Conclusion: Expression level of miR-375 in peripheral blood of pregnant women with GDM during the second trimester of pregnancy increases abnormally, which has certain value for predicting the postpartum abnormal glucose metabolism of these women.
|
|
|
|
|
|
|
|
|
