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| Expressions and significances of miR-590 and miR-16 in uterine tissue of patients with uterine leiomyoma and its significances |
| Gynecology and Obstetrics Department, 988 hospital of the Joint Logistic Support forces，Zhengzhou, 450007 |
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Abstract To detect the expression levels of miR-590 and miR-16 in uterine tissues patients with uterine leiomyoma, to analyze the relationship between the expression levels of miR-590 and miR-16 in uterine tissues and the occurrence of uterine leiomyoma, and to study their clinical significances. Methods: 64 patients with uterine leiomyoma from January 2016 to December 2018 were selected in study group, and another 64 patients with uterine prolapse who underwent hysterectomy were selected in control group during the same time. The expression levels of miR-590 and miR-16 in uterine tissues of patients in the two groups were detected by qRT-PCR, and the relationships between the levels of miR-590 and miR-16 and hormone levels of patients with uterine leiomyoma, and the risk factors of uterine leiomyoma were analyzed by logistic regression. Results: The expression levels of Mir-590 and Mir-16 of patients in the study group were 0.52±0.14 and 0.46±0.11, which were significant lower than those (1.03±0.31 and 1.01±0.27) of patients in the control group, but the serum levels of estradiol (E2), progesterone (P), folliclestimulating hormone (FSH), and luteinizing hormone (LH) of patients in the study group were significant higher (all P＜0.05). The expression levels of Mir-590 and Mir-16 were negatively correlated with the E2 and P levels. The E2 and P levels elevated, and the expression of Mir-590 and Mir-16 decreased were risk factors of uterine fibroids (all P＜0.05). Conclusion: The expressions of miR-590 and miR-16 in uterine leiomyoma tissues are low, and are negatively correlated with their E2 and P levels, which may be related to the occurrence and development of uterine leiomyoma.
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