Abstract To observe the clinical effect of microscopically ligation of spermatic vein (MSV) combined with zinc gluconate for treating patients with varicocele induced infertility, and to study the changes of the serum INHB and HIF-1α levels of the patients. Methods: 87 patients with bilateral varicocele were selected and randomly divided into two groups from January 2017 to March 2019. 43 patients in the treatment group had been treated by MSV combined with zinc gluconate for three months, and 44 patients in the control group had been treated by MSV alone. The semen quality before and after treatment, treatment efficiency, reproductive endocrine hormone levels, trace element zinc changes, serum and seminal plasma HIF-1α levels of patients, pregnancy rate of their wives in 24 months followed up, and other indicators were compared between the two groups. Results: 6 months after treatment, the therapeutic effect of patients in the treatment group was 90.7%, which was significant higher than that (70.5%) of patients in the control group, and the amount of semen, a and b type sperm motility, the sperm density, and the serum levels of INH B and T, and the levels of serum and seminal plasma zinc of patients in the treatment group were also significant higher than those of patients in the control group, but the proportion of teratospermia, serum LH, FSH levels, and the serum and seminal plasma HIF-1α levels of patients in the treatment group were significant lower than those of patients in the control group (all P＜0.05). During the 24 months followed up period, the pregnancy rate of the wives of patients in the treatment group was 74.4%, which was significant higher than that(47.7%) of patients in the control group (P＜0.05). Conclusion: MSV combined with zinc gluconate for treating patients with varicocele induced infertility can effectively improve their reproductive endocrine function, correct the imbalance of trace element zinc, promote sperm production, improve sperm quality, and can improve the pregnancy rate of the patients' spouses.
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