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| Analysis of the levels of VEGF, Hcy and HIF-1αand the risk factors of patients with missed abortion |
| The Second Hospital of Wuxi Affiliated to Nanjing Medical University, Jiangsu Province, 214000 |
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Abstract To explore the changes of the levels of serum vascular endothelial growth factor (VEGF), high homocysteine (Hcy), and hypoxia inducible factor-1α(HIF-1α) of patients with missed abortion, and to analyze the risk factors of missed abortion. Methods: 42 patients with missed abortion were included in observation group, and 42 normal pregnant women who wanted induced abortion were included in control group. The levels of VEGF, Hcy and HIF-1α of patients were compared between the two groups. And single factor analysis and logistic regression analysis were used for statistical analysis of the clinical data of patients. Results: The levels of VEGF and HIF-1α of patients in the observation group were significant lower than those of patients in the control group (P<0.05). The results of variance analysis showed that there was significant different in proportions of the older women, smoking history, radiation overdose accepted, folic acid supplementation, knowledge of reproduction, or abnormal thyroid function of patients between the two groups. Logistic regression analysis showed that older women, smoking history, radiation overdose accepted, thyroid dysfunction and Hcy level were the risk factors for missed abortion, while folic acid supplementation, high level of reproductive knowledge, and levels of VEGF and HIF-1α were the protective factors for missed abortion (all P<0.05). Conclusion: The levels of serum VEGF, Hcy and HIF-1α, older women, smoking history, radiation overdose accepted, folic acid supplementation, knowledge level of reproduction, and abnormal thyroid function were all closely related to missed abortion.
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