Abstract Objective: To investigate the effect of different iodine nutrient level of pregnant women during the first, second or third trimesters of pregnancy on their thyroid function and thyroid hormone levels. Method: 210 pregnant women were selected in this study from May 2018 to February 2019, which included 72 women in group A (during the first trimesters of pregnancy), 70 women in group B (during the second trimesters of pregnancy) and 68 women in group C (during the third trimesters of pregnancy). The levels of urine iodine, serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) of women were detected and compared among the three groups. Results: The rate of iodine deficiency of women in group A was 38.9%, which was significant higher than those of women in group B and C (P<0.05). Thyroid dysfunction of women in group A and B was mainly manifested as hypoFT4 and subclinical hypothyroidism, and the hyperthyroidism might exist in a few women in group C. The thyroid dysfunction rate of women with iodine deficiency in group A was 66.7%, which was significant higher than that of women in group B or C (P<0.05). The incidence of thyroid dysfunction of women with iodine overdose in group C was 30.0%, which was significant higher than that of women in group A or B (P<0.05). Conclusion: Iodine nutrition level of pregnant women during the second or third trimesters of pregnancy is basically appropriate, but iodine deficiency is still prevalent during the first pregnancy. The iodine nutritional level of pregnant women, especially those women during the first of pregnancy, should be closely monitored. If the pregnant women with urinary iodine < 150 ug/L or > 250 ug/L, their thyroid function should be screened.
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