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| The efficacy of FH combined with TCT or high-risk HPV detection for screening cervical cancer and precancerous lesions |
| The First Affiliated Hospital of Zhengzhou University, Henan Province, 450000 |
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Abstract Objective: To evaluate the efficacy of FH of cervical cells combined with TCT or high-risk HPV detection for screening cervical cancer and precancerous lesions. Methods: 128 women who had experience cervical cancer screening were selected as subjects from January 2016 to January 2018. All these included women underwent gynecological examination, cervical histopathological examination, FH, TCT and high-risk HPV detection, and were all confirmed by cervical histopathological examination lastly. Pathological diagnosis showed 13 women with cervical precancerous lesions, which included 5 women with HSIL and 8 women LSIL. 3 women with cervical cancer and 112 women without any cervical lesions were confirmed by pathological examination. ROC curve was used to analyze the efficacy of FH, TCT and high-risk HPV detection for screening cervical cancer and precancerous lesions. Results: The area under ROC curve (AUC) of FH, TCT and high-risk HPV detection were 0.814, 0.895 and 0.937, respectively. There was no significant difference between FH and TCT (P>0.05), but the screening efficacy of cervical cancer HPV detection was the best. The AUC of FH combined with TCT, FH combined with HPV, and TCT combined with HPV were 0.793, 0.903 and 0.950, respectively, which of TCT combined with HPV was the best. Conclusion: FH detection as uterine epithelial cell stability has the advantages of simple operation, fast, and low cost for screening cervical cancer, which screening efficacy is similar to that of TCT, but slightly worse than that of HPV detection, so FH detection combined with TCT or HPV detection can improve the accuracy of diagnosis.
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