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| The influence of different doses of hormone for treating patients with perimenopausal syndrome on their hormone and lipid metabolism |
| Guang'an People's Hospital, Sichuan Province, 638000 |
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Abstract Objective: To analyze the curative effect of three different doses of hormone for treating perimenopausal syndrome (PMS), and to study its influences on reproductive hormone and glycolipid metabolism of women with PMS. Methods: A total of 120 women with PMS were given menopause hormone therapy (MHT), and were randomly divided into group A (ultra low dose of MHT), group B (low dose of MHT), and group C (standard dose MHT) from June 2016 to November 2018. The levels of reproductive hormone, luteinizing hormone (LH), estradiol (E2) and follicle stimulating hormone (FSH) and glycolipid metabolism indexes, endometrial thickness (IMT), number of antral follicle count (AFC), and adverse reactions rate of women were compared among the three groups. Results: The effective rate of women in group B and C were 92.5% and 95.0%, which was significant higher than that (75.0%) of women in group A (P< 0.05). After treatment, both LH and FSH levels of women in the three groups had decreased significantly, while E2 level had increased significantly, and the change degree of the levels of LH, FSH and E2 of women in group C was the highest (P<0.05). After treatment, IMT and AFC level of women in group B and group C were significant higher than that of women in group A (P<0.05), and the incidence of adverse reactions of women in group C was significant higher than that of women in group A and B (P<0.05). Conclusion: Compared with those of low dose or ultra low dose of MHT used, the effect of standard dose for treating women with PMS has better in improving reproductive hormone level and glycolipid metabolism indexes. Low dose and standard dose MHT used has the similar effect in improving IMT and AFC. However, standard dose MHT used maybe have more adverse reactions, so the appropriate treatment options should be based on the actual situations of women with PMS.
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