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| Relationship between serum miR-26b expression of women with polycystic ovarian syndrome and their glycolipid metabolism |
| Jiangbei Campus of Zhongda Hospital affilitated to Southeast University，Nanjing, Jiangsu Province, 210000 |
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Abstract Objective: To study the relationship between serum micro-RNA-26b (miR-26b) expression of women with polycystic ovarian syndrome (PCOS) and their glycolipid metabolism. Methods: 80 women with PCOS were selected into observation group from March 2016 to January 2019, and another 80 infertility women without PCOS were included in control group during the same time. The expression of serum miR-26b and indexes of women were compared between the two groups, and the correlation between the expression of serum miR-26b and the glycolipid metabolism indexes levels was analyzed. The expression of serum miR-26b of women in the observation group was analyzed by multiple stepwise regression analysis. Results: The levels of fasting blood glucose(FBG), triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), fasting insulin (FINS), and miR-26b, and insulin resistance index (HOMA-IR) value of women in the observation group were significant higher than those of women in the control group (P<0.05). Pearson method had showed that the expression of serum miR-26b of women in the observation group was positively correlated with their LDL-C level and values of HOMA-IR and BMI (P<0.05). Multiple stepwise regression analysis showed that HOMA-IR was a risk factor of the serum miR-26b expression of women in the observation group (OR>1). Conclusion: The expression of serum miR-26b of women with PCOS is closely related to their glucolipid metabolism, and HOMA-IR is a risk factor of their serum miR-26b expression. As a monitoring target in clinical practice, serum miR-26b level can provide evidence for clinical diagnosis and treatment of women with PCOS.
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